{"id":276,"date":"2022-12-24T21:55:30","date_gmt":"2022-12-24T21:55:30","guid":{"rendered":"https:\/\/chinesebay.com\/sf\/%e9%9b%b7%e6%98%a5%e6%9d%82%e6%96%87%ef%bc%9amrna%e7%96%ab%e8%8b%97%e7%a7%91%e6%99%ae\/"},"modified":"2022-12-24T21:55:30","modified_gmt":"2022-12-24T21:55:30","slug":"%e9%9b%b7%e6%98%a5%e6%9d%82%e6%96%87%ef%bc%9amrna%e7%96%ab%e8%8b%97%e7%a7%91%e6%99%ae","status":"publish","type":"post","link":"https:\/\/chinesebay.com\/sf\/%e9%9b%b7%e6%98%a5%e6%9d%82%e6%96%87%ef%bc%9amrna%e7%96%ab%e8%8b%97%e7%a7%91%e6%99%ae\/","title":{"rendered":"\u96f7\u6625\u6742\u6587\uff1amRNA\u75ab\u82d7\u79d1\u666e"},"content":{"rendered":"

\u96f7\u6625\u6742\u6587\uff1amRNA\u75ab\u82d7\u79d1\u666e<\/p>\n

\u5199\u4e8e2020\u5e74\u611f\u6069\u8282\u524d\u5915<\/p>\n

<\/p>\n

\u524d\u8a00<\/h2>\n

\u4eba\u4f53\u7684\u9632\u5fa1\u7cfb\u7edf\uff0c\u662f\u4e00\u4e2a\u6709\u6761\u6709\u7406\u3001\u7cbe\u786e\u7ec6\u81f4\u7684\u590d\u6742\u4f53\u7cfb\u3002<\/p>\n

\u5982\u679c\u62ff\u53f8\u6cd5\u548c\u519b\u961f\u505a\u6bd4\u55bb\uff0c\u5bf9\u4e8e\u5c11\u91cf\u7684\uff0c\u5bf9\u56fd\u5bb6\u6574\u4f53\u5b89\u5168\u5a01\u80c1\u4e0d\u5927\u7684\u201c\u4e0d\u6cd5\u5206\u5b50\u201d, \u4e00\u4e9b\u767d\u7ec6\u80de\u8b66\u5bdf\u4f1a\u81ea\u52a8\u5c06\u5b83\u4eec\u201c\u902e\u6355\u201d\u3001\u201c\u6cd5\u529e\u201d\u3002\u8fd9\u76f8\u5f53\u4e8e\u89e3\u51b3\u56fd\u5bb6\u5185\u90e8\u95ee\u9898\u3001\u751a\u81f3\u56fd\u9645\u95f4\u8c0d\u7ec4\u7ec7\u7684\u6d3b\u52a8\u3002\u514d\u75ab\u5b66\u79f0\u4f5c\u5148\u5929\u514d\u75abInnate immunity\u3002\u4ee5\u4e0a\u8fd9\u4e9b\u957f\u76f8\u4e0d\u540c\u7684\u767d\u7ec6\u80de\uff0c\u662f\u8eab\u4f53\u7684\u7b2c\u4e00\u9053\u5b89\u5168\u9632\u7ebf\u3002<\/p>\n

\u4f46\u662f\uff0c\u5982\u679c\u8fb9\u9632\u54e8\u6240\u7684\u5de1\u903b\u5175\u6216\u8005\u6563\u5e03\u5404\u5730\u7684\u7279\u5de5\u4eba\u5458\uff08\u6297\u4f53\uff09\uff0c\u53d1\u73b0\u4e86\u654c\u4eba\uff08\u6297\u539f\uff09\uff0c\u5165\u4fb5\u56fd\u5bb6\u8fb9\u5883\u6216\u8005\u4f01\u56fe\u5236\u9020\u6050\u6016\u88ad\u51fb\u65f6\uff0c\u4f1a\u4e0a\u62a5\u201c\u519b\u4e8b\u9886\u5bfc\u201d\uff0c\u7ec4\u7ec7\u201c\u64d2\u62ff\u201d\u3001\u201c\u9632\u5fa1\u201d\u6216\u201c\u53cd\u653b\u201d\u3002\u8fd9\u79cd\u9632\u5fa1\u673a\u5236\uff0c\u6839\u636e\u4e8b\u6001\u7684\u4e25\u91cd\u6027\uff0c\u9700\u8981\u8c03\u96c6\u4e0d\u540c\u7684\u519b\u4e8b\u3001\u653f\u6cbb\u529b\u91cf\u3002\u514d\u75ab\u5b66\u79f0\u4f5c\u540e\u5929\u514d\u75abadaptive immunity\u3002\u75ab\u82d7\u662f\u5e2e\u52a9\u8eab\u4f53\u5efa\u7acb\u540e\u5929\u514d\u75abadaptive immunity\u7684\u4e00\u4e2a\u9014\u5f84\u3002\u5176\u4e2d\uff0cB\u7ec6\u80de\u548cT\u7ec6\u80de\u662f\u4e24\u5927\u4e0d\u540c\u4f46\u53c8\u4e92\u4f5c\u7684\u9632\u5fa1\u529b\u91cf\uff0c\u5982\u679c\u8bf4B\u7ec6\u80de\u662f\u51b2\u950b\u9677\u9635\u7684\u6d77\u9646\u519b\u5b98\u5175\uff0cT\u7ec6\u80de\u53ef\u4ee5\u8bf4\u6210\u662f\u9ad8\u7ea7\u6307\u6325\u3001\u56fd\u5bb6\u5b89\u5168\u90e8\u3001\u56fd\u9632\u90e8\uff0c\u4ee5\u53ca\u5177\u6709\u5927\u89c4\u6a21\u6740\u4f24\u529b\u7684\u201c\u7a7a\u519b\u201d\u751a\u81f3\u201c\u822a\u6bcd\u201d\uff1bB\u7ec6\u80de\u5177\u6709\u5feb\u901f\u53cd\u5e94\u80fd\u529b\uff0cT\u7ec6\u80de\u9762\u5411\u5168\u5c40\u3002<\/p>\n<\/p>\n

\u7b2c\u4e00\u90e8\u5206 \u514d\u75ab\u53cd\u5e94\u4e4b\u4e00 \uff1a\u6d77\u9646\u519b\u77ed\u5203\u76f8\u63a5<\/h2>\n

\u4f53\u6db2\u514d\u75abHumoral Immunity<\/p>\n

<\/p>\n

\u8fd9\u4e2a\u56fe\u663e\u793a\uff1a\u7531B\u7ec6\u80de\u6f14\u5316\u6765\u7684\u6d46\u7ec6\u80de\u5927\u91cf\u4ea7\u751f\u6297\u4f53\u7684\u8fc7\u7a0b\u3002<\/p>\n

B\u7ec6\u80de\u8868\u9762\u7684\u6297\u4f53\u5bf9\u75c5\u6e90\u7684\u8bc6\u522b\uff0c\u76f8\u5f53\u4e8e\u8fb9\u9632\u54e8\u6240\u7684\u5b98\u5175\u6355\u6293\u4e86\u95f4\u8c0d\u6216\u5c0f\u80a1\u654c\u519b\u3002\u7ecf\u8fc7\u4e25\u5bc6\u5ba1\u8baf\uff0c\u654c\u519b\u7684\u4fe1\u606f\u88ab\u5199\u6210\u62a5\u544a\uff08\u6297\u6e90\u548cMHC\u5206\u5b50\u7ed3\u5408\uff09\uff0c\u62a5\u7ed9\u6709\u519b\u4e8b\u6307\u6325\u6743\u7684\u4e0a\u7ea7\uff08\u6210\u719fT\u7ec6\u80de a mature matching T-cell\uff09\u3002\u519b\u4e8b\u957f\u5b98\uff08T\u7ec6\u80de\uff09\u8ba4\u5b9a\u654c\u519b\u7684\u610f\u56fe\u540e\uff0c\uff08\u901a\u8fc7\u7ec6\u80de\u56e0\u5b50cytokines\uff09\u4e0b\u8fbe\u6307\u4ee4\uff0c\u589e\u52a0\u8bc6\u522b\u8fd9\u79cd\u654c\u4eba\u7684\u8fb9\u9632\u90e8\u961f\uff08\u5927\u91cf\u589e\u6b96\u5bf9\u8fd9\u79cd\u6297\u6e90\u6709\u7279\u5f02\u6027\u7684B\u7ec6\u80de\uff09\uff0c\u5176\u4e2d\u7684\u6b66\u88c5\u90e8\u961f\uff08\u6d46\u7ec6\u80deplasma cell\uff09\u5bf9\u6240\u6709\u53d1\u73b0\u7684\u654c\u519b\u5c55\u5f00\u8fdb\u653b\uff08\u91ca\u653e\u6297\u4f53\uff09\uff0c\u529b\u56fe\u5728\u654c\u4eba\u8fd8\u6ca1\u7ad9\u4f4f\u811a\u7684\u65f6\u5019\uff0c\u4e00\u4e3e\u5c06\u5176\u6d88\u706d\u3002\u540c\u65f6\uff0c\u8bbe\u7f6e\u4e13\u95e8\u5e94\u5bf9\u8fd9\u7c7b\u654c\u4eba\u7684\u673a\u6784\uff08\u8bb0\u5fc6B\u7ec6\u80deMemory B Cell\uff09\u3002\u8fd9\u4e2a\u56fe\u663e\u793a\uff1aB\u7ec6\u80de\u4f1a\u6f14\u53d8\u6210\u4e24\u7c7b\uff1a\u8bb0\u5fc6B\u7ec6\u80de\u548c\u6d46\u7ec6\u80de\u3002\u8bb0\u5fc6B\u7ec6\u80de\u5bf9\u75c5\u6e90\u7684\u518d\u6b21\u5165\u4fb5\u4f1a\u6709\u6781\u5feb\u7684\u53cd\u5e94\uff0c\u4ea7\u751f\u5927\u91cf\u7684\u6297\u4f53\uff0c\u8fc5\u901f\u94f2\u9664\u75c5\u6e90\u3002<\/p>\n

\n \u7b2c\u4e8c\u90e8\u5206 \u514d\u75ab\u53cd\u5e94\u4e4b\u4e8c\uff1a\u7a7a\u519b\u6216\u822a\u6bcd\u4f5c\u6218<\/h2>\n

\u7ec6\u80de\u514d\u75abCell Mediated Immunity <\/p>\n

<\/p>\n

\u8fd9\u4e2a\u56fe\u663e\u793a\uff1aT\u7ec6\u80de\u6f14\u5316\u6210\u6740\u624bT\u7ec6\u80de\uff08Killer T Cell\uff09\u53c8\u79f0\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\uff08CCytotoxic T cell\uff09\u7684\u8fc7\u7a0b\u3002<\/p>\n

\u5f53\u654c\u4eba\u5df2\u7ecf\u7a81\u7834\u7b2c\u4e00\u9053\u6d77\u9646\u519b\u9632\u7ebf\uff0c\u96c6\u7ed3\u4e8e\u5883\u5185\uff08\u4fb5\u5165\u7ec6\u80de\uff09\u540e\uff0c\u70ae\u5175\u5766\u514b\u519b\uff08\u5de8\u566c\u7ec6\u80demacrophage\uff09\u5f00\u59cb\u56f4\u653b\u88ab\u654c\u519b\u5360\u9886\u7684\u5730\u533a\uff08\u88ab\u611f\u67d3\u7684\u7ec6\u80de\uff09\uff0c\u5728\u6d88\u706d\u5e76\u6293\u6355\u5230\u5176\u53f8\u4ee4\u5934\u5b50\u540e\uff0c\u5411\u56fd\u9632\u90e8\uff08\u8bb0\u5fc6T\u7ec6\u80deMemory T Cell\uff09\u5448\u9012\u6218\u7565\u90e8\u7f72\u6587\u4ef6\uff08\u6297\u6e90-MHC\u4e0e\u8bb0\u5fc6T\u7ec6\u80de\u53d7\u4f53\u7ed3\u5408\uff09\uff0c\u540c\u65f6\uff0c\u4e5f\u5411\u56fd\u5bb6\u5b89\u5168\u90e8 (\u8f85\u52a9 T\u7ec6\u80deHelper T Cell) \u63d0\u4f9b\u4fe1\u606f\uff08\u6297\u6e90-MHC\u4e0e\u8f85\u52a9T\u7ec6\u80de\u53d7\u4f53\u7ed3\u5408\uff09\u3002\u56fd\u5bb6\u5b89\u5168\u90e8 (\u8f85\u52a9T\u7ec6\u80de)\u53d1\u4fe1\u606f\uff08\u7ec6\u80de\u56e0\u5b50Cytokines\uff09\u7ed9\u56fd\u9632\u90e8\uff08\u8bb0\u5fc6T\u7ec6\u80de\uff09\uff0c\u786e\u5b9a\u654c\u4eba\u7684\u89c4\u6a21\uff08\u5927\u91cf\u88ab\u611f\u67d3\u7684\u7ec6\u80de\uff09\u540e\uff0c\u96c6\u7ed3\u7a7a\u519b\uff08\u589e\u6b96T\u7ec6\u80de\uff09\uff0c\u6839\u636e\u5730\u6807\uff08\u611f\u67d3\u7ec6\u80de\u8868\u9762\u7684\u6297\u6e90\u6807\u8bb0\uff09\uff0c\u901a\u8fc7\u8f70\u70b8\u673a\u6295\u653e\u6bd2\u6c14\u5f39\uff08\u6740\u624bT\u7ec6\u80de\u91ca\u653e\u7ec6\u80de\u56e0\u5b50\uff09\uff0c\u6b7c\u706d\u6574\u4e2a\u9635\u8425\u7684\u654c\u4eba\uff08\u6740\u6b7b\u88ab\u611f\u67d3\u7684\u7ec6\u80de\uff09\u3002\u540c\u65f6\uff0c\u56fd\u9632\u90e8\uff08\u8bb0\u5fc6T\u7ec6\u80de\uff09\u5bf9\u654c\u4eba\u5907\u6848\uff0c\u65f6\u523b\u76d1\u63a7\uff0c\u4e00\u65e6\u518d\u5ea6\u5165\u4fb5\uff0c\u4f1a\u8fc5\u901f\u51fa\u51fb\uff0c\u6d88\u706d\u654c\u4eba\u4e8e\u521d\u671f\u3002<\/p>\n

\u7b2c\u4e09\u90e8\u5206\uff1a\u6297\u539f\u548c\u6297\u4f53<\/h2>\n

Antigen and Antibody <\/p>\n


\n \u8fd9\u4e2a\u56fe\u663e\u793a\uff1a\u6297\u539f\u548c\u6297\u4f53\u662f\u4e00\u628a\u94a5\u5319\u5f00\u4e00\u628a\u9501\u7684\u5173\u7cfb\uff0c\u6709\u7cbe\u51c6\u7684\u7279\u5f02\u6027\u3002<\/p>\n<\/p>\n


\n \u8fd9\u4e2a\u56fe\u663e\u793a\u6297\u4f53\u7684\u4e09\u79cd\u4f5c\u7528\uff1a1. \u4e2d\u548c\u4f5c\u7528\uff0c\u6297\u4f53\u963b\u6b62\u75c5\u6bd2\u6216\u8005\u6bd2\u6027\u86cb\u767d\u4e0e\u53d7\u4f53\u7ec6\u80de\u7ed3\u5408\uff1b2. \u534f\u52a9\u541e\u566c\u4f5c\u7528\uff0c\u75c5\u6e90\u83cc\u6216\u75c5\u6bd2\uff0c\u56e0\u6297\u4f53\u7684\u9644\u7740\u800c\u88ab\u8bc6\u522b\u5e76\u541e\u566c\uff1b3. \u8865\u4f53\u7cfb\u7edf\u4f5c\u7528\uff0c\u6297\u4f53\u7684\u9644\u7740\u76f4\u63a5\u5bfc\u81f4\u75c5\u539f\u8868\u9762\u5f62\u6210\u5b54\u6d1e\u800c\u89e3\u4f53\u3002<\/p>\n


\n \u8fd9\u4e2a\u56fe\u663e\u793a\uff1a\u5de8\u566c\u7ec6\u80de\u4e0d\u4ec5\u541e\u5165\u75c5\u83cc\u6216\u8005\u53d7\u75c5\u6bd2\u611f\u67d3\u7684\u7ec6\u80de\uff0c\u8fd8\u4f1a\u5e2e\u52a9\u514d\u75ab\u7ec6\u80de\u8bc6\u522b\u8fd9\u4e9b\u5165\u4fb5\u8005\u3002<\/p>\n

\u7b2c\u56db\u90e8\u5206 \u4f20\u7edf\u706d\u6d3b\u75ab\u82d7\u3001\u51cf\u6d3b\u75ab\u82d7\u548c\u75c5\u6bd2\u8f7d\u4f53\u75ab\u82d7<\/h2>\n


\n \u4f20\u7edf\u7684\u706d\u6d3b\u75ab\u82d7\uff0c\u4ee5\u6d41\u611fRNA\u75c5\u6bd2\u4e3a\u4f8b\uff0c\u662f\u7ecf\u8fc7\u5728\u53d7\u7cbe\u7684\u9e21\u86cb\u80da\u80ce\u4e2d\u751f\u957f\u3001\u5206\u79bb\u540e\uff0c\u5728\u4e00\u5b9a\u7684\u6e29\u5ea6\u4f5c\u7528\u4e0b\u5bfc\u81f4\u5176\u5931\u53bb\u6d3b\u6027\uff0c\u518d\u6ce8\u5165\u4eba\u4f53\u7684\u3002\u4eba\u4f53\u7684\u514d\u75ab\u7cfb\u7edf\uff0c\u8bc6\u522b\u8868\u9762\u86cb\u767d\uff0c\u5bf9\u5b83\u4ea7\u751f\u514d\u75ab\u53cd\u5e94\uff0c\u5236\u9020\u6d46\u7ec6\u80de\u548c\u8bb0\u5fc6B\u7ec6\u80de\u3002\u56e0\u4e3a\u6d41\u611fRNA\u53d8\u5f02\u5f88\u5feb\uff0c\u6bcf\u5e74\u6d41\u884c\u7684\u75c5\u6bd2\u8868\u9762\u86cb\u767d\u7684\u7ed3\u6784\u90fd\u6709\u53d8\u5316\uff0c\u5fc5\u987b\u6bcf\u5e74\u90fd\u9884\u6d4b\u540e\u91cd\u7ec4\u75ab\u82d7\u3002\u5305\u62ec\u7684\u75c5\u6bd2\u79cd\u7c7b\u8d8a\u591a\uff0c\u6709\u6548\u6027\u8d8a\u597d\uff0c\u76ee\u524d\u6709\u56db\u4ef7\u75ab\u82d7\u3002\u8fd9\u79cd\u4f20\u7edf\u75ab\u82d7\u751f\u4ea7\u7684\u5468\u671f\u6bd4\u8f83\u957f\uff0c\u5bf9\u9e21\u86cb\u8fc7\u654f\u7684\u4eba\u4e0d\u9002\u5408\u6253\u3002<\/p>\n<\/p>\n

\u51cf\u6d3b\u75ab\u82d7\u662f\u81f4\u75c5\u7684\u75c5\u6bd2\u5728\u66f4\u6362\u5bbf\u4e3b\u53ca\u4f20\u4ee3\u7684\u8fc7\u7a0b\u4e2d\u201c\u51cf\u6d3b\u201d\uff0c\u6bd2\u6027\u548c\u7e41\u6b96\u529b\u51cf\u5f31\uff0c\u4f46\u6297\u539f\u4fdd\u6301\u4e0d\u53d8\u3002\u6d41\u611f\u51cf\u6d3b\u75c5\u6bd2\u662f\u9e21\u7684\u80da\u80ce\u91cc\u7e41\u6b96\u7684\u3002\u75c5\u6bd2\u5b66\u5bb6Shen\u535a\u58eb\u8bf4\uff1a\u201c\u65b0\u51a0\u75c5\u6bd2\u51cf\u6d3b\u75ab\u82d7\u7684\u98ce\u9669\u5f88\u5927\u3002\u4e00\u65e6\u51cf\u6d3b\u7684\u7a0b\u5ea6\u4e0d\u591f\uff0c\u6216\u8005\u65b0\u51a0\u51cf\u6d3b\u75c5\u6bd2\u5728\u4f53\u5185\u7531\u4e8e\u67d0\u4e9b\u539f\u56e0\u6d3b\u5f97\u66f4\u591a\u6d3b\u529b\uff0c\u53cd\u800c\u5c31\u771f\u7684\u6b63\u5e38\u611f\u67d3\u4e86\u4ece\u800c\u4f20\u64ad\u66f4\u591a\u5176\u4ed6\u4eba\u3002\u75c5\u60c5\u4e5f\u53ef\u80fd\u6076\u5316\u3002\u6240\u4ee5\u73b0\u5728\u4e00\u822c\u6bd4\u8f83\u4e25\u91cd\uff08\u4f20\u67d3\u98ce\u9669\u6216\u8005\u53d1\u75c5\u540e\u679c\u6bd4\u8f83\u4e25\u91cd\uff09\u7684\u4f20\u67d3\u75c5\uff0c\u5982\u679c\u6709\u5176\u4ed6\u75ab\u82d7\u7684\u9009\u62e9\u4f59\u5730\uff0c\u4e0d\u8981\u7528\u51cf\u6d3b\u75ab\u82d7\u7684\u5f62\u5f0f\u3002\u201d <\/p>\n

\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u7684\u75c5\u6bd2\u8f7d\u4f53\u65b0\u51a0\u75ab\u82d7\uff0c\u6709\u817a\u75c5\u6bd2\u548cRSV\u4e24\u79cd\u75c5\u6bd2\u8f7d\u4f53\u65b0\u51a0\u75ab\u82d7\uff0c\u75c5\u6bd2\u8f7d\u4f53\u5c06\u65b0\u51a0\u7684S\u86cb\u767d\u9057\u4f20\u7269\u8d28\u5e26\u5165\u7ec6\u80de\uff0c\u8feb\u4f7f\u53d7\u611f\u67d3\u7684\u7ec6\u80de\u8868\u8fbe\u65b0\u51a0S\u86cb\u767d\uff0c\u8bf1\u53d1\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n

\u514d\u75ab\u529b\u4f4e\u7684\u4eba\u4e0d\u5408\u9002\u7528\u4efb\u4f55\u6d3b\u75c5\u6bd2\u75ab\u82d7\u3002<\/p>\n

<\/p>\n

\u75c5\u6bd2\u518d\u6b21\u4fb5\u88ad\u65f6\uff0c\u8bb0\u5fc6B\u7ec6\u80de\u4f1a\u8fc5\u901f\u7e41\u6b96\u7279\u5f02\u7684\u6d46\u7ec6\u80de\u3001\u4ea7\u751f\u5927\u91cf\u6297\u4f53\u3002\u8bb0\u5fc6T\u7ec6\u80de\u4e5f\u4f1a\u5728\u8bc6\u522b\u611f\u67d3\u7684\u7ec6\u80de\u540e\u8fc5\u901f\u6295\u6bd2\uff0c\u6740\u6b7b\u88ab\u611f\u67d3\u7684\u7ec6\u80de\u3002<\/p>\n

\n \u7b2c\u4e94\u90e8\u5206 \u65b0\u51a0mRNA\u75ab\u82d7<\/h2>\n

<\/p>\n

\u8fd9\u4e2a\u56fe\u663e\u793a\uff1a\u65b0\u51a0\u75c5\u6bd2\u8868\u9762\u7684\u7a81\u8d77\u86cb\u767d(Spike Protein)\uff0c\u7b80\u79f0S\u86cb\u767d\uff0c\u662f\u8bf1\u53d1\u514d\u75ab\u53cd\u5e94\u7684\u4e3b\u8981\u56e0\u7d20\u3002\u8fd9\u79cd\u86cb\u767d\u8fd8\u6709\u4e0d\u540c\u7684\u4e9a\u57fa\uff08subunit\uff09\u3002\u5236\u9020mRNA\u75ab\u82d7\u7684\u516c\u53f8\uff0c\u9996\u5148\uff0c\u8981\u6839\u636eS\u86cb\u767d\u7684\u7acb\u4f53\u7a7a\u95f4\u7ed3\u6784\u53ca\u5e8f\u5217\u7684\u4fdd\u5b88\u6027\u8bbe\u8ba1\u6700\u4f73\u6297\u539f\uff1b\u5176\u6b21\uff0c\u8981\u8bbe\u8ba15\u2019 Cap\u7aef\u7684\u975e\u86cb\u767d\u7ffb\u8bd1\u5e8f\u5217\uff0c\u4fdd\u8bc1\u5176\u5728\u7ec6\u80de\u4e2d\u7684\u9ad8\u4ea7\u6027\u53ca\u5206\u5b50\u7684\u7a33\u5b9a\u6027\uff1b\u7b2c\u4e09\uff0c\u8981\u8bbe\u8ba1\u51fa\u6700\u4f73\u7684\u591aA\u5c3e\u5df4\uff08Poly A Tail\uff09\u7684\u957f\u5ea6\uff0c\u4f7f\u5f97\u4eba\u5de5\u5408\u6210\u7684mRNA\u5206\u5b50\u5728\u7ec6\u80de\u4e2d\u6709\u8f83\u957f\u7684\u4e0d\u88ab\u964d\u89e3\u7684\u65f6\u95f4\uff0c\u8fbe\u5230\u5927\u91cf\u4ea7\u751fS\u86cb\u767d\uff0c\u8bf1\u53d1\u514d\u75ab\u53cd\u5e94\u7684\u76ee\u7684\u3002<\/p>\n

\u8fd9\u4e2a\u56fe\u663e\u793a\uff1a\u88f8\u9732\u7684mRNA\u5f88\u5bb9\u6613\u88ab\u7a7a\u6c14\u4e2d\u3001\u6c34\u4e2d\u65e0\u5904\u4e0d\u5728\u7684RNA\u9176\u964d\u89e3\uff0c\u51e0\u4e4e\u4e0d\u53ef\u80fd\u76f4\u63a5\u6ce8\u5c04\u540e\u5230\u8fbe\u7ec6\u80de\u5185\u90e8\uff0c\u7ffb\u8bd1\u86cb\u767d\u3002\u5b83\u9700\u8981\u4fdd\u62a4\u548c\u8f7d\u4f53\u3002mRNA\u75ab\u82d7\u662f\u5229\u7528\u7eb3\u7c73\u8102\u8d28\u7684\u5305\u88c5\u6765\u907f\u514d\u88abRNA\u9176\u964d\u89e3\u7684\u3002\u8102\u8d28\u4f5c\u4e3a\u8f7d\u4f53\uff0c\u8d77\u7740\u4fdd\u62a4\u548c\u8fd0\u8f93\u4e24\u4e2a\u4f5c\u7528\u3002<\/p>\n

<\/p>\n

\u8fd9\u4e2a\u56fe\u663e\u793a\uff1a\u8102\u8d28\u5305\u88c5\u7684mRNA\u4e0e\u7ec6\u80de\u819c\u878d\u5408\u540e\u8fdb\u5165\u7ec6\u80de\uff0c\u5e76\u5229\u7528\u7ec6\u80de\u7684\u86cb\u767d\u5408\u6210\u7cfb\u7edf\u751f\u4ea7S\u86cb\u767d\u3002<\/p>\n

<\/p>\n

\u8fd9\u4e2a\u56fe\u663e\u793a\uff1a\u7ec6\u80de\u5206\u6ccc\u7684\u6e38\u79bb\u4e8e\u4f53\u6db2\u7684S\u86cb\u767d\u4f1a\u8bf1\u5bfcB\u7ec6\u80de\u4ea7\u751f\u6297\u4f53\uff0c\u5e76\u4ea7\u751f\u8bb0\u5fc6B\u7ec6\u80de\u3002\u56fe\u4e2d\u6ca1\u6709\u663e\u793a\u7684\u60c5\u51b5\u8fd8\u6709\uff0c\u7ec6\u80de\u819c\u8868\u9762\u7684S\u86cb\u767d\uff0c\u4f1a\u8bf1\u53d1T\u7ec6\u80de\u7684\u514d\u75ab\u53cd\u5e94\uff0c\u4ea7\u751f\u8bb0\u5fc6T\u7ec6\u80de\uff0c\u4e3a\u6740\u6b7b\u88ab\u75c5\u6bd2\u5165\u4fb5\u7684\u7ec6\u80de\u505a\u51c6\u5907\u3002<\/p>\n<\/p>\n

\u5927\u90e8\u5206mRNA\u5728\u4eba\u4f53\u7ec6\u80de\u91cc\u7684\u5bff\u547d\u53ea\u6709\u51e0\u5206\u949f\uff0c\u8fd9\u662f\u9ad8\u7b49\u751f\u7269\u7684\u57fa\u56e0\u8c03\u63a7\u673a\u5236\u7684\u4e00\u90e8\u5206\u3002\u56e0\u6b64\uff0c\u76f8\u5f53\u957f\u7684\u65f6\u95f4\u91cc\uff0c\u51e0\u4e4e\u6ca1\u6709\u4eba\u8ba4\u4e3amRNA\u53ef\u4ee5\u5236\u4f5c\u6210\u75ab\u82d7\u3002<\/p>\n

\u7ecf\u8fc7\u4e09\u5341\u591a\u5e74\u79d1\u5b66\u5bb6\u4eec\u7684\u4e0d\u65ad\u52aa\u529b\uff0cmRNA\u75ab\u82d7\u7684\u5173\u952e\u6280\u672f\u6709\u4e86\u7a81\u7834\uff1a<\/p>\n

1.\u8bbe\u8ba1\u5408\u6210\u7684mRNA\u7684\u7a33\u5b9a\u6027\u76f8\u5bf9\u8f83\u597d\uff0c\u4e0d\u5bb9\u6613\u88ab\u964d\u89e3\u5931\u6d3b\uff1b<\/p>\n

2.\u878d\u5408\u8fdb\u5165\u7ec6\u80de\u540e\uff0c\u5176\u5bff\u547d\u548c\u7ffb\u8bd1\u86cb\u767d\u7684\u6d3b\u6027\u5ef6\u957f\u81f3\u51e0\u5929\uff1b<\/p>\n


\n 3. \u5305\u88c5mRNA\u7684\u8102\u8d28\uff08lipid\uff09\u662f\u6b63\u7535\u7eb3\u7c73\u7c92\u5b50\uff0c\u4e0d\u4ec5\u7a33\u5b9a\u6027\u597d\uff0c\u53ef\u4ee5\u4fdd\u62a4\u8d1f\u7535\u7684mRNA\uff0c\u8fd8\u53ef\u4ee5\u548c\u53cc\u5c42\u8d1f\u7535\u78f7\u9178\u916f\uff08phosphate lipid bilayer\uff09\u7ec6\u80de\u819c\u4eb2\u548c\uff0c\u5e2e\u52a9mRNA\u8f93\u5165\u7ec6\u80de\u3002<\/p>\n

\u7eb3\u7c73\u8102\u8d28\u5982\u679c\u8fc7\u5927\uff0c\u4e0d\u5bb9\u6613\u964d\u89e3\uff0c\u5bf9\u7ec6\u80de\u4f1a\u6709\u6bd2\u6027\uff1b\u5982\u679c\u8fc7\u5c0f\uff0c\u5bf9mRNA\u7684\u4fdd\u62a4\u6027\u3001\u4ee5\u53ca\u4e0e\u7ec6\u80de\u819c\u7684\u878d\u5408\u6027\u90fd\u4f1a\u5dee\u3002Pfizer\u548cMaderna\u4e24\u5bb6\u516c\u53f8\u5728\u8fd9\u65b9\u9762\u7684\u6280\u672f\u4f1a\u6709\u4e00\u4e9b\u5dee\u5f02\u3002
\n Pfizer\u7684\u75ab\u82d7\u7a33\u5b9a\u6027\u5dee\uff0c\u9700\u8981\u96f6\u4e0b\u8d1f70\u6444\u6c0f\u5ea6\u7684\u4f4e\u6e29\u4fdd\u5b58\uff0c\u800cModerna\u53ef\u4ee5\u5728\u96f6\u4e0b20\u6444\u6c0f\u5ea6\u4fdd\u5b586\u4e2a\u6708\u3002\u5176\u5dee\u5f02\u5f88\u53ef\u80fd\u662f\u8102\u8d28\u5927\u5c0f\u4e0d\u540c\u3002Pfizer\u867d\u7136\u7a33\u5b9a\u6027\u5dee\uff0c\u4f46\u56e0\u4e3a\u8102\u8d28\u8f83\u5c0f\u3001\u964d\u89e3\u5feb\uff0c\u526f\u4f5c\u7528\u4e5f\u5c31\u76f8\u5bf9\u8f7b\u4e00\u70b9\u3002<\/p>\n


\n \u8fd9\u4e2a\u56fe\u663e\u793a\uff1a\u7b2c\u4e8c\u6b21\u6ce8\u5c04\u75ab\u82d7\u4f1a\u5927\u5927\u589e\u52a0\u8bb0\u5fc6\u7ec6\u80de\u7684\u6570\u91cf\uff0c\u4e3a\u6297\u4f53\u7684\u4ea7\u751f\u548c\u6740\u624b\u7ec6\u80de\u7684\u5f62\u6210\u63d0\u4f9b\u6761\u4ef6\uff0c\u8fbe\u5230\u9632\u75c5\u6bd2\u4fb5\u5bb3\u7684\u76ee\u7684\u3002<\/p>\n

Pfizer\u7684mRNA\u75ab\u82d7\u56fe\u793a\u3002\n <\/p>\n

AstraZeneca\u7684\u817a\u75c5\u6bd2\u8f7d\u4f53\u65b0\u51a0\u75ab\u82d7\u56fe\u793a\u3002<\/p>\n

AstraZeneca\u516c\u53f8\u7684<\/strong>\u817a\u75c5\u6bd2\u4f5c\u4e3a\u8f7d\u4f53\u7684\u65b0\u51a0\u75ab\u82d7\u4e5f\u5728\u4e34\u5e8a\u5b9e\u9a8c\u4e2d\u53d6\u5f97\u4e86\u5f88\u5927\u6210\u529f\u3002\u817a\u75c5\u6bd2\u8f7d\u4f53\u5c06\u65b0\u51a0\u7684S\u86cb\u767d\u5e8f\u5217\u7684DNA\u5e26\u5165\u7ec6\u80de\uff0c\u8fdb\u5165\u7ec6\u80de\u6838\uff0c\u8f6c\u5f55\u6210mRNA\uff0c\u8feb\u4f7f\u53d7\u611f\u67d3\u7684\u7ec6\u80de\u8868\u8fbe\u65b0\u51a0S\u86cb\u767d\uff0c\u5e76\u88ab\u5206\u6ccc\u5230\u7ec6\u80de\u8868\u9762\u548c\u7ec6\u80de\u5916\uff0c\u8bf1\u5bfc\u8bb0\u5fc6T\u7ec6\u80de\u3001\u8bb0\u5fc6B\u7ec6\u80de\u4ee5\u53ca\u6297\u4f53\u7684\u4ea7\u751f\u3002\u56e0\u4e3aDNA\u6bd4\u8f83\u7a33\u5b9a\uff0c\u817a\u75c5\u6bd2\u65b0\u51a0\u75ab\u82d7\u7684\u4f18\u70b9\u662f\u53ef\u4ee5\u5e38\u6e29\u4fdd\u5b58\uff0c\u4fbf\u4e8e\u8fd0\u8f93\u3002<\/p>\n<\/p>\n

\u7b2c\u516d\u90e8\u5206 mRNA\u75ab\u82d7\u7684\u529f\u8fc7<\/p>\n

\u4ece\u7406\u8bba\u4e0a\u8bf4\uff0cmRNA\u7684\u4f5c\u7528\u6709\u4ee5\u4e0b\u51e0\u79cd\u8003\u8651\uff1a<\/p>\n

1. \u8102\u8d28\u7684\u6bd2\u6027\u3002\u8fd9\u4e9b\u4eba\u5de5\u5408\u6210\u7684\u8102\u8d28\uff0c\u4f5c\u4e3a\u8f7d\u4f53\uff0c\u5c06\u4fb5\u5165\u7ec6\u80de\u3002\u6ce8\u5c04\u90e8\u4f4d\u7684\u7ec6\u80de\u79cd\u7c7b\u4e0d\u540c\uff0c\u5bf9\u8fd9\u79cd\u8102\u8d28\u7684\u53cd\u5e94\u4e5f\u5c31\u4e0d\u540c\u3002\u8102\u8d28\u9897\u7c92\u8d8a\u5927\uff0c\u6bd2\u6027\u8d8a\u5927\uff0c\u964d\u89e3\u4e5f\u8d8a\u6162\u3002\u76ee\u524d\u770b\u5230\u7684\u4e24\u5bb6\u516c\u53f8\u7684\u4e34\u5e8a\u7ed3\u679c\uff0c\u526f\u4f5c\u7528\u65f6\u95f4\u4e0d\u957f\uff0c\u90fd\u5728\u53ef\u4ee5\u8010\u53d7\u8303\u56f4\u5185\u3002<\/p>\n

2. mRNA\u7684\u5e8f\u5217\u548c\u7ffb\u8bd1\u7684\u86cb\u767d\u4e5f\u53ef\u80fd\u9020\u6210\u67d0\u79cd\u53cd\u5e94\u3002\u6709\u7bc7\u6587\u7ae0\u4e2d\u63d0\u5230\u901a\u8fc7\u52a0\u5165RNA\u590d\u5236\u9176\u7cfb\u5217\u6765\u5ef6\u957f\u86cb\u767d\u8d28\u4ea7\u51fa\u65f6\u95f4\u3002\u8fd9\u89e3\u91ca\u4e86\u4e00\u822c\u53ea\u80fd\u5b58\u5728\u51e0\u5206\u949f\u7684mRNA\uff0c\u5982\u4f55\u5728\u51e0\u5929\u540e\u8fd8\u80fd\u7ffb\u8bd1\u751f\u4ea7\u86cb\u767d\u3002\u8fd9\u79cd\u9176\u4e0d\u662f\u4eba\u4f53\u672c\u8eab\u6709\u7684\uff0c\u662f\u5426\u4f1a\u88ab\u4eba\u4f53\u514d\u75ab\u7cfb\u7edf\u8bc6\u522b\uff0c\u9020\u6210\u6ca1\u6709\u9884\u6599\u5230\u7684\u53cd\u5e94\uff0c\u8fd8\u9700\u8981\u89c2\u5bdf\u3002<\/p>\n

3. mRNA\u75ab\u82d7\u6ca1\u6709\u9006\u8f6c\u5f55\u9176\u7684\u5e8f\u5217\uff0c\u4fb5\u5165\u4eba\u4f53\u7ec6\u80de\u7684\u57fa\u56e0\u7ec4\u7684\u53ef\u80fd\u6027\u4e3a\u96f6\u3002\u8fd9\u662f\u4f18\u4e8e\u6709\u9006\u8f6c\u5f55\u9176\u7684RNA\u75c5\u6bd2\u8f7d\u4f53\uff0c\u4ee5\u53caDNA\u8f7d\u4f53\u75ab\u82d7\u7684\u5730\u65b9\u3002<\/p>\n

4. mRNA\u75ab\u82d7\u4fdd\u5b58\u548c\u8fd0\u8f93\u6240\u9700\u7684\u4f4e\u6e29\uff0c\u5982\u679c\u6ca1\u6709\u4e25\u683c\u6267\u884c\uff0c\u4e0d\u77e5\u4f1a\u9020\u6210\u4ec0\u4e48\u6837\u7684\u6bd2\u526f\u4f5c\u7528\uff1b\u6216\u8005\u6253\u4e86\u65e0\u6548\uff0c\u4e5f\u4f1a\u662f\u8d1f\u9762\u7684\u56e0\u7d20\u3002<\/p>\n

5. ADE\uff08Antibody-dependent enhancement\uff09\u6297\u4f53\u4f9d\u8d56\u7684\u589e\u5f3a\u4f5c\u7528\u662f\u201c\u975e\u4e2d\u548c\u6027\u6297\u4f53\u201d\u9644\u7740\u75c5\u6bd2\u540e\u5438\u5f15\u5de8\u566c\u7ec6\u80de\u541e\u566c\uff0c\u4f46\u53c8\u4e0d\u5bfc\u81f4\u5176\u964d\u89e3\uff0c\u53cd\u800c\u5728\u7ec6\u80de\u5185\u590d\u5236\uff0c\u9020\u6210\u66f4\u5927\u611f\u67d3\u6027\u7684\u526f\u4f5c\u7528\u3002\u4eca\u5e745\u6708\u53d1\u8868\u5728\u81ea\u7136\u6742\u5fd7\u4e0a\u7684\u6587\u7ae0\uff0c\u7efc\u8ff0\u4e86\u75ab\u82d7\u548c\u6297\u4f53\u7684ADE\u81f4\u75c5\u673a\u7406\u3002\u4e8c\u671f\u548c\u4e09\u671f\u4e34\u5e8a\u4f1a\u5bf9ADE\u8fdb\u884c\u6df1\u5165\u89c2\u5bdf\u548c\u7814\u7a76\uff0c\u75ab\u82d7\u516c\u53f8\u5728\u8fd9\u65b9\u9762\u5e94\u8be5\u4e0d\u6562\u9a6c\u864e\u3002\u76ee\u524d\u51fa\u7ed3\u679c\u7684\u4e09\u5bb6\u516c\u53f8\uff08Pfizer\u3001Moderna\u548cAstraZeneca\uff09\u8fd8\u6ca1\u6709\u75c5\u4f8b\u3002\u56fe\u793a\uff1a\u75ab\u82d7\u548c\u6297\u4f53\u7684ADE\u81f4\u75c5\u673a\u7406\u3002<\/p>\n


\n \u8fd9\u5f20\u56fe\u663e\u793a\uff1aRBD\u90e8\u5206\u662fS\u86cb\u767d\u7684\u514d\u75ab\u8bc6\u522b\u4f4d\u70b9\uff0c\u4e5f\u662fmRNA\u75ab\u82d7\u7684\u5e8f\u5217\u8bbe\u8ba1\u90e8\u5206\u3002\u76f8\u5bf9\u6574\u4e2a\u75c5\u6bd2\u6216\u8005\u5b8c\u6574\u7684S\u86cb\u767d\uff0c\u5229\u7528RBD\u4e9a\u57fasubunit\u5e8f\u5217\u5236\u9020\u7684\u75ab\u82d7\uff0c\u4e0d\u5bb9\u6613\u8bf1\u53d1\u975e\u4e2d\u548c\u6027\u6297\u4f53\u7684\u4ea7\u751f\uff0cADE\u526f\u4f5c\u7528\u7684\u53ef\u80fd\u6027\u4e5f\u5c31\u5927\u5927\u964d\u4f4e\u4e86\u3002<\/p>\n

\u7ed3\u675f\u8bed<\/p>\n

mRNA\u75ab\u82d7\u662f\u4e00\u4e2a\u5168\u65b0\u7684\u75ab\u82d7\uff0c\u5728\u8fc7\u53bb\u7684\u4e09\u5341\u591a\u5e74\u95f4\uff0c\u4ece\u79d1\u5b66\u7814\u7a76\u89d2\u5ea6\uff0c\u6709\u4e86\u6781\u5927\u7684\u53d1\u5c55\u3002\u8fd9\u6b21\u65b0\u51a0\u7684\u8086\u8650\uff0c\u7ed9\u4e86\u5b83\u5927\u5c55\u8eab\u624b\u7684\u673a\u4f1a\uff0c\u4f46\u4e5f\u7ed9\u4eba\u4eec\u5fc3\u7406\u5e26\u6765\u4e0d\u5c0f\u7684\u6311\u6218\u3002\u662f\u5426\u76f8\u4fe1\u5b83\u7684\u5b89\u5168\u6027\u3001\u53ef\u9760\u6027\u548c\u6709\u6548\u6027\uff0c\u6210\u4e86\u6c11\u4f17\u5173\u5207\u7684\u8bdd\u9898\u3002<\/p>\n

\u6211\u8fd9\u7bc7\u79d1\u666e\u6587\u7ae0\u7684\u76ee\u7684\u4e0d\u662f\u7ed9\u4f60\u4e00\u4e2a\u786e\u5207\u7684\u7b54\u6848\uff0c\u800c\u662f\u5e0c\u671b\u5927\u5bb6\u6839\u636e\u79d1\u5b66\u77e5\u8bc6\u6765\u4e3a\u81ea\u5df1\u7684\u5065\u5eb7\u505a\u51b3\u5b9a\u3002\u5373\u4f7f\u5728\u533b\u5b66\u754c\uff0c\u4e5f\u6709\u8d5e\u540c\u548c\u53cd\u5bf9\u7684\u58f0\u97f3\u3002<\/p>\n

\u6211\u5148\u751f\u4f5c\u4e3a\u533b\u751f\uff0c\u63a5\u89e6\u5230\u65e0\u75c7\u72b6\u6709\u611f\u67d3\u6027\u7684\u65b0\u51a0\u75c5\u4eba\u7684\u673a\u4f1a\u8f83\u9ad8\uff0c\u4ed6\u4f1a\u4e49\u65e0\u53cd\u987e\u5730\u63a5\u53d7\u7b2c\u4e00\u6279\u75ab\u82d7\u3002\u6211\u4f5c\u4e3a\u5168\u804c\u9ad8\u4e2d\u8001\u5e08\uff0c\u5728\u8fc7\u53bb\u7684\u51e0\u4e2a\u6708\uff0c\u5df2\u7ecf\u548c\u65b0\u51a0\u5b66\u751f\u64e6\u80a9\u800c\u8fc7\u4e86\u51e0\u6b21\uff0c\u5fc3\u6709\u4f59\u60b8\uff0c\u5982\u679c\u6709\u75ab\u82d7\u53ef\u4ee5\u63a5\u79cd\uff0c\u6211\u4e0d\u4f1a\u9519\u8fc7\u65f6\u673a\u3002<\/p>\n

\u5e0c\u671b\u5927\u5bb6\u90fd\u5b89\u5168\u5ea6\u8fc7\u8fd9\u4e2a\u96be\u5173\uff0c\u66d9\u5149\u5728\u524d\u3002<\/p>\n

\u611f\u6069\u8282\u5feb\u4e50\uff01<\/p>\n<\/p>\n

https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3597572\/#!po=0.510204 <\/p>\n

https:\/\/www.nature.com\/articles\/nrd.2017.243<\/a> <\/p>\n

https:\/\/www.nature.com\/articles\/s41541-020-0159-8<\/a><\/p>\n

https:\/\/www.nature.com\/articles\/s41564-020-00789-5.pdf<\/a><\/p>\n

https:\/\/en.m.wikipedia.org\/wiki\/Humoral_immunity<\/a><\/p>\n

https:\/\/en.m.wikipedia.org\/wiki\/Cell-mediated_immunity<\/a><\/p>\n

https:\/\/en.m.wikipedia.org\/wiki\/Antigen<\/a><\/p>\n

https:\/\/www.vaccines.gov\/basics\/types<\/a><\/p>\n

https:\/\/openstax.org\/books\/concepts-biology\/pages\/17-3-adaptive-immunity#fig-ch17_03_04<\/p>\n

https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/vaccines\/different-vaccines\/how-they-work.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fcoronavirus%2F2019-ncov%2Fvaccines%2Fabout-vaccines%2Fhow-they-work.html<\/p>\n

https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/vaccines\/different-vaccines\/mRNA.html<\/p>\n

https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(20)31237-X <\/p>\n

https:\/\/www.pei.de\/SharedDocs\/Downloads\/EN\/newsroom-en\/dossiers\/ppt-erste-studie-sars-cov-2-impfstoff-en.pdf?__blob=publicationFile&v=7<\/a><\/p>\n

https:\/\/pfe-pfizercom-d8-prod.s3.amazonaws.com\/PFIZER-MRNA_Vaccine-COVID_Infographic_final_square.png<\/a> <\/p>\n

https:\/\/www.pfizer.com\/news\/hot-topics\/covid_19_vaccine_u_s_distribution_fact_sheet<\/a><\/p>\n

https:\/\/www.nejm.org\/doi\/full\/10.1056\/nejmoa2022483<\/a> (Moderna Clinical trial result)<\/p>\n

https:\/\/www.modernatx.com\/modernas-work-potential-vaccine-against-covid-19<\/a><\/p>\n

https:\/\/www.astrazeneca.com\/media-centre\/press-releases\/2020\/azd1222hlr.html<\/a><\/p>\n

https:\/\/www.statnews.com\/2020\/11\/10\/the-story-of-mrna-how-a-once-dismissed-idea-became-a-leading-technology-in-the-covid-vaccine-race\/<\/a><\/p>\n

https:\/\/www.wsj.com\/articles\/moderna-and-pfizer-are-reinventing-vaccines-starting-with-covid-11605638892<\/a><\/p>\n

https:\/\/www.cnbc.com\/2020\/11\/23\/covid-vaccine-cdc-should-warn-people-the-side-effects-from-shots-wont-be-walk-in-the-park-.html<\/a><\/p>\n

https:\/\/www.biospace.com\/article\/another-covid-19-vaccine-joins-the-race-this-time-it-s-a-live-weakened-virus\/<\/a><\/p>\n

http:\/\/life.nthu.edu.tw\/~bioclass\/files\/980111%20class-1.pdf<\/a><\/p>\n

https:\/\/www.raps.org\/news-and-articles\/news-articles\/2020\/3\/covid-19-vaccine-tracker<\/a><\/p>\n

https:\/\/www.washingtonpost.com\/graphics\/2020\/health\/covid-vaccine-update-coronavirus\/<\/a><\/p>\n

https:\/\/www.mdpi.com\/2076-393X\/8\/3\/404\/htm<\/a><\/p><\/p>\n

<\/div>
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